Cefuroxime 500 mg Clavulanic 125 mg

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Cefuroxime is a bactericidal second generation cephalosporin antibiotic which is active against a wide range of Gram-positive and Gram-negative susceptible organisms including many beta-lactamase producing strains. Cefuroxime inhibits bacterial cell wall synthesis by interfering with the transpeptidation process.

Clavulanic acid is a naturally derived beta lactamase inhibitor produced by Streptomyces clavuligerus. It has similar structure to beta lactam antibiotics which binds irreversibly to beta-lactamase enzymes and inactivates them. Clavulanic acid gives protection of Cefuroxime from degradation by beta lactamase enzymes and provides a solution for the treatment of bacterial infections caused by beta lactam resistant bacteria.

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    Cefuroxime 500 mg + Clavulanic Acid 125 mg is a potent fixed-dose combination antibiotic that targets a wide range of bacterial infections, especially those caused by resistant organisms. It is a fixed combination of Cefuroxime, which is a second-generation cephalosporin antibiotic, and Clavulanic Acid, a beta-lactamase inhibitor. Both together offer improved efficacy against bacteria that produce beta-lactamase enzymes—substances that often inactivate many antibiotics. This combination is most effective when taken for the treatment of respiratory tract, urinary tract (UTI), skin and soft tissue infections, and certain sinusitis.


    Cefuroxime Axetil – 500 mg

    Clavulanic Acid (as potassium clavulanate) – 125 mg

    The two components have synergistic action to give broad-spectrum activity against Gram-positive and Gram-negative bacteria, including resistant strains like Haemophilus influenzae, Moraxella catarrhalis, Staphylococcus aureus, Streptococcus pneumoniae, and certain strains of Escherichia coli and Klebsiella pneumoniae.


    Mechanism of Action

    Cefuroxime prevents bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), eventually causing cell lysis and death.

     

    Clavulanic Acid is a suicide inhibitor of the beta-lactamase enzyme. Though it possesses little or no antibacterial action as a standalone drug, it inhibits the enzymatic degradation of Cefuroxime, hence increasing its efficacy.

     

    This synergistic mechanism renders the combination extremely effective even in infections where the usual cephalosporins would be unsuccessful.


    Indications

    Cefuroxime 500 mg + Clavulanic Acid 125 mg is indicated for the treatment of a wide spectrum of bacterial infections, including:

     

    Upper respiratory infections: Pharyngitis, tonsillitis, otitis media, and sinusitis

     

    Lower respiratory infections: Acute bronchitis, exacerbations of chronic bronchitis, and pneumonia due to community-acquired pathogens

     

    Urinary tract infections (UTIs): Cystitis and pyelonephritis

     

    Skin and soft tissue infections: Cellulitis, impetigo, and wound infections

     

    Post-operative infection: Particularly due to beta-lactamase-producing pathogens


    Dosage and Administration

    The adult dose is one tablet containing 500 mg/125 mg every 12 hours.

     

    Tablets must be administered after meals to maximize absorption and reduce gastrointestinal side effects.

     

    Treatment duration is normally 5 to 10 days based on the severity and nature of the infection.

     

    Always adhere to the doctor’s prescription, and take the entire course even if relief is noticed early to avoid recurrence or resistance.


    Contraindications

    This medication is contraindicated in the following:

     

    Individuals with known hypersensitivity to cephalosporins, penicillins, or to any component of the preparation

     

    Individuals with a history of prior severe allergic reaction (e.g., anaphylaxis) to beta-lactam antibiotics


    Precautions and Warnings

    Renal insufficiency: Dosage should be reduced in individuals with impaired kidney function.

     

    Liver disease: Use with caution; liver function tests should be monitored at regular intervals.

     

    Pregnancy and lactation: Use only when indicated and by a health care provider. Cefuroxime is Pregnancy Category B.

     

    Hypersensitivity reactions: Observe for rash, urticaria, or anaphylaxis. Stop if these are noted.

     

    Superinfection: Long-term therapy may result in overgrowth of nonsusceptible bacteria such as Candida or Clostridium difficile causing pseudomembranous colitis.


    Adverse Effects

    Side effects that are common:

    Nausea and vomiting

    Diarrhea

    Abdominal discomfort

    Headache

    Rash or skin reactions

    Uncommon but serious effects:

    Hepatic impairment (elevated liver enzymes)

    Blood dyscrasias (e.g., eosinophilia, thrombocytopenia)

    Severe hypersensitivity (Stevens-Johnson Syndrome, anaphylaxis)


    Drug Interactions

    Antacids and proton pump inhibitors: Reduce the absorption of Cefuroxime. Administer at least 2 hours apart.

     

    Oral contraceptives: Concomitant use of antibiotics reduces the efficacy of hormonal contraceptives. Use alternative non-hormonal methods.

     

    Diuretics and nephrotoxic agents: Co-administration enhances the risk of kidney toxicity.


    Storage Instructions

    Store in a cool, dry place below 25°C.

     

    Keep the drug in its original blister pack to avoid contact with moisture and light.

     

    Beyond the reach of children.

     

    Cefuroxime 500 mg + Clavulanic Acid 125 mg is a very effective, broad-spectrum antibiotic drug combination against resistant and difficult-to-treat bacterial infections. Its enhanced activity by beta-lactamase inhibition makes it a valuable option in the treatment of serious to severe infections in clinical practice and community practice. As an antibiotic, like all the others, it has to be used cautiously under the supervision of physicians to prevent antimicrobial resistance and maximum therapeutic effects.


    Order Now At Mdx Pharma bd….

    To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

     

    1. What is the purpose of cefixime clavulanic acid?
    Potassium plus cefixime Typhoid fever, gonorrhea, and severe bacterial infections of the skin, tonsils, throat, lungs, and urinary tract are treated with clavulanate or clavulanic acid.

     

    2. Does Cefuroxime outperform Augmentin?
    In conclusion, when it comes to treating upper respiratory tract infections, cefuroxime axetil at a dose of 250 mg b.d. seems to be just as safe and effective as Augmentin at the larger dose of 375 mg t.d.s.

     

    3. What is the purpose of cefotaxime clavulanic acid?
    According to the Kirby-Bauer Method, bacterial cultures are tested for antimicrobial susceptibility using cefotaxime/clavulanic acid CEC 30/10 mcg.

     

    4. What is the purpose of Xiclav?
    Clavulanic acid, the second active component, stops this. The following infections can be treated with Xiclav®: respiratory infections, sinus infections, and middle ear infections.

    Generic Name:

    Cefuroxime & Clavulanic Acid

    Theraputic Category:

    Antibiotic

    Pack Size:

    (250 mg + 62.5 mg : 2×7's), (500 mg + 125 mg : 2×7's)