Cabozantinib is a strong multi-kinase inhibitor that is used to treat a number of tumors, such as medullary thyroid cancer (MTC), hepatocellular carcinoma (HCC), and renal cell carcinoma (RCC). One of the strengths of cabozantinib that is available for oral administration is the 80 mg dosage. It is sold under the names Cometriq for MTC and Cabometyx for advanced RCC and HCC.

Pharmacological

Cabozantinib functions by blocking many tyrosine kinases that are implicated in angiogenesis, metastasis, and tumor formation. It mainly targets three proteins that are essential for tumor growth, vascularization, and resistance mechanisms: MET (mesenchymal-epithelial transition factor), AXL (anaplastic lymphoma kinase), and VEGFR (vascular endothelial growth factor receptor).

Cabozantinib decreases tumor angiogenesis, inhibits tumor cell invasion, and strengthens the immune system’s defenses against cancer cells by blocking these pathways. Patients with advanced-stage cancers have better survival rates thanks to this mechanism, which also helps halt the progression of the disease.

Dosage and Administration

Cabozantinib at a dosage of 80 mg is typically provided as part of a regimen that is frequently modified in response to adverse effects and patient tolerance. For RCC and HCC, a starting dose of 60 mg once daily is usually advised; however, in certain circumstances, larger or lower doses may be needed. In reaction to side effects, dose reductions (to 40 mg or 20 mg) can be required.

To optimize absorption, patients should take cabozantinib empty-handed, at least an hour before or two hours after meals. It’s crucial to swallow the tablet whole with water rather than breaking it up or chewing it.

Side Effects and Precautions

Cabozantinib has a number of side effects, ranging from minor to severe, like many targeted medicines. Typical negative reactions include the following:

Gastrointestinal problems include vomiting, nausea, diarrhea, and appetite loss.

Fatigue: Feeling weak and exhausted

Increased blood pressure, or hypertension

Hand-foot syndrome, or palmar-plantar erythrodysesthesia: Skin reactions on the palms and soles

Increased protein in the urine is known as proteinuria.

Hepatotoxicity: Increase of liver enzymes

Gastrointestinal perforation, poor wound healing, and arterial thromboembolic events are severe but uncommon side effects. Patients should be watched for abnormalities in liver function, hypertension, and bleeding symptoms.

Drug Interactions

Cabozantinib is metabolized by the enzyme CYP3A4, hence its plasma levels may be impacted by potent inducers (like rifampin) or inhibitors (like ketoconazole). St. John’s wort and grapefruit should be avoided by patients since they may change how drugs are metabolized.

Conclusion

Cabozantinib 80 mg is a vital therapeutic choice for those with advanced cancer. It improves outcomes in RCC, HCC, and MTC by efficiently targeting many kinases implicated in tumor growth and survival. To guarantee patient safety and treatment effectiveness, however, cautious dose management and monitoring are necessary due to its possible adverse effects.

Order Now At Mdx Pharma bd….

To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

1. Are Cabometyx and Cabozantinib interchangeable?
One kind of targeted cancer medication is cabotanzantinib. Ka-boe-zan-tih-nib is how you pronounce it. Another name for it is Cabometyx.

2. How long does CABOMETYX treatment last?
Nivolumab and CABOMETYX together in first-line advanced RCC When used with intravenous nivolumab at a dose of 240 mg every two weeks or 480 mg every four weeks, the recommended dosage of CABOMETYX is 40 mg once daily. Until the condition worsens or the toxicity becomes intolerable, the treatment should be continued.

3. Does Cabometyx reduce the size of tumors?
Tumors may cease growing or even shrink after using CABOMETYX. The development of blood vessels that supply the tumor may be inhibited by CABOMETYX. It might also aid in the body’s destruction of cancerous cells.

4. Is hair loss a Cabometyx adverse effect?
Notify your doctor or pharmacist right once if any of these side effects persist or worsen. Hair loss may be temporary. Following therapy, normal hair growth should resume. Serious side effects are possible for those using this medicine.

5. Can cancers be shrunk by cabozantinib?
The results, which were published in Nature Cancer, challenge conventional wisdom regarding neoadjuvant therapy—treatment administered prior to surgery to help shrink tumors and improve surgical outcomes—by indicating that cabozantinib not only reduces tumor size but also boosts immune activity within the tumor microenvironment.