Venetoclax 100 mg (Venclexta)

0.00$

Venetoclax, derived from Venetoclax INN, is a medication employed for treating chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and acute myeloid leukemia (AML) in specific patient groups. It falls under the category of BCL-2 inhibitors, which function by obstructing the B-cell lymphoma 2 (BCL-2) protein, facilitating the programmed cell death (apoptosis) of cancerous cells. Typically, Venetoclax is administered alongside other chemotherapy agents and has demonstrated promising outcomes in enhancing overall survival rates and progression-free survival among individuals affected by these hematologic malignancies.

Add to wishlist
Share

    Venetoclax, which is retailed under the brand name Venclexta, is an oral tradition drug that’s employed in the operation of some types of blood cancers. It’s a BCL- 2 asset, i.e., a drug that specifically targets and inhibits a particular protein that’s employed by cancer cells to remain alive. By suppressing the protein, Venetoclax helps to beget cell death among the cancer cells, thereby being an extremely useful drug in targeted cancer remedy.

    Venclexta is available in colorful strengths, including 100 mg tablets, a standard cure administered either alone or as part of a gradational cure escalation approach at treatment inauguration.


    Indications and Uses

    Venetoclax has been approved by medicine nonsupervisory bodies like the FDA for use in the treatment of

    habitual Lymphocytic Leukemia( CLL) or Small Lymphocytic Carcinoma( SLL) with or without 17p omission

    Acute Myeloid Leukemia( AML) in grown-ups 75 times and aged, or with comorbidities that render ferocious chemotherapy unhappy

    In CLL and SLL, Venetoclax is generally administered alone or in combination with other medicines similar as obinutuzumab or rituximab, depending on the treatment authority. For AML, it’s generally administered with azacitidine, decitabine, or low- cure cytarabine.


    How Venetoclax Works

    Venetoclax is a picky B- cell carcinoma- 2( BCL- 2) protein asset. The BCL- 2 protein is overexpressed in the maturity of cancers, especially hematologic cancers, and allows cancer cells to shirk the normal process of apoptosis( programmed cell death). Venetoclax triggers apoptosis by inhibiting BCL- 2 and leads to the reduction of cancer cells in the body.

    This medium is a type of targeted remedy, so it has smaller side goods compared to traditional chemotherapy, but it still needs to be nearly covered.


    Dosage and Administration

    The Venetoclax 100 mg (Venclexta) tablet is generally part of a ramp- up dosing schedule when initiating remedy. This cure increase is necessary to reduce the threat of a potentially fatal complication known as Excrescence Lysis Pattern( TLS) that occurs when cancer cells break down fleetly.

    A typical dosing schedule for CLL can look like

    Week 1 20 mg diurnal

    Week 2 50 mg diurnal

    Week 3 100 mg formerly daily

    Week 4 200 mg formerly daily

    Week 5 and beyond 400 mg formerly daily( conservation cure)

    Note These boluses must be titrated grounded on individual case conditions, laboratory results, and attendant specifics.


    Side Effects

    Like any drug, Venetoclax has side goods, some of which are serious. Side goods include

    Low blood counts( neutropenia, anemia, thrombocytopenia)

    Constipation or diarrhea

    Fatigue

    Nausea

    Infections( including upper respiratory tract infections)

    Major pitfalls include

    Excrescence Lysis Pattern( TLS) – life- hanging due to the breakdown of cancer cells too fleetly

    Severe infections – pneumonia and sepsis

    Liver function abnormality

    Close monitoring with frequent blood work and clinical evaluations is necessary during treatment, especially during the first ramp-up period.


    Warnings and Precautions

    Before starting Venetoclax, cases should

    Be estimated for threat of TLS

    Havepre-treatment blood work and order function tests

    Get acceptable hydration and, in some cases, preventative drugs like allopurinol

    Venetoclax also interacts with several specifics that affect the CYP3A enzymes, similar as antifungals( e.g., ketoconazole), certain antibiotics, andanti-seizure specifics. A thorough drug review is thus essential.

    The medicine isn’t recommended during gestation or breastfeeding due to the pitfalls to the fetus or child.


    Storage and Handling

    Venetoclax 100 mg tablets should be

    At room temperature( 20 – 25 °C or 68 – 77 °F)

    In the original vessel with the lid forcefully closed

    Down from humidity and out of the reach of children

    Cases should take advice from their druggist and noway give this drug to anyone.


    Conclusion

    Venetoclax 100 mg( Venclexta) is a precious new addition to the treatment of certain blood cancers, offering a targeted remedy that improves issues for a large number of cases. While a veritably useful treatment, it requires close medical supervision due to the eventuality for serious side effects, particularly with the original dosing cycle. Cases specified Venclexta should maintain close follow- ups with their health care provider, cleave to dosing instructions precisely, and report any concerning symptoms incontinently.


    Order Now At Mdx Pharma bd….

    To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

     

    1. What’s Venetoclax 100 mg( Venclexta) used for?
    Venetoclax is used to treat certain types of blood cancer, including
    habitual lymphocytic leukemia( CLL)
    Small lymphocytic carcinoma( SLL)
    Acute myeloid leukemia( AML)( with other specifics)
    It works by targeting and blocking BCL- 2, a protein that helps cancer cells survive.

     

    2. How does Venetoclax work?
    Venetoclax blocks the B- cell carcinoma- 2( BCL- 2) protein, which is typically overexpressed in some types of cancer. By blocking the protein, Venetoclax induces apoptosis( cell death), and this reduces the number of cancer cells.

     

    3. How is Venetoclax administered?
    Venetoclax is taken daily by mouth. Take the tablets whole with water during a mess to reduce the threat of some side effects. The cure is escalated over several weeks to reduce the threat of excrescence lysis pattern( TLS).

     

    4. Can Venetoclax be used in combination with other specifics?
    Some medicines can interact with Venetoclax, including those affecting CYP3A enzymes( certain antifungals, antibiotics, anticonvulsants, and grapefruit products). Be sure to inform your croaker of all medicines, vitamins, or supplements that you’re taking.

     

    5. How should I store Venetoclax tablets?
    Store Venetoclax at room temperature between 20 – 25 °C( 68 – 77 °F) and in a defended manner from humidity and light. Store in the original vessel until use and down from children.

     

    6. Is Venetoclax safe when pregnant or breastfeeding?
    No. Venetoclax may harm a growing future baby and mustn’t be taken during gestation or breastfeeding. Women who can come pregnant need to use effective birth control during treatment and for 30 days after the case’s last cure. Men also need to use birth control as Venetoclax may affect sperm.

    Product Name

    Ventoxen

    Generic Name :

    Venetoclax INN

    Formulation

    Tablet

    Available Pack size

    60 Tablets

    Strengths

    100 mg