Cabozantinib is an effective small-molecule tyrosine kinase inhibitor (TKI) that is mainly used to treat a number of cancers, such as medullary thyroid cancer (MTC), hepatocellular carcinoma (HCC), and renal cell carcinoma (RCC). A higher-strength formulation of cabozantinib, the 80 mg dosage is usually administered based on the needs of each patient, the course of the disease, and tolerability.

Pharmacological Profile

Cabozantinib targets several tyrosine kinases, such as MET, VEGFR (vascular endothelial growth factor receptor), AXL, and RET, to produce its therapeutic effects. These kinases are important for angiogenesis, metastasis, and tumor growth. Cabozantinib efficiently lowers tumor proliferation, stops the blood supply to tumors, and stops the spread of malignant cells by blocking these pathways.

Dosage and Administration

Cabozantinibis offered as tablets containing 20 mg, 40 mg, and 80 mg of various strengths. For some malignancies, the 80 mg pill is frequently used as part of the conventional treatment plan; the daily dose should not exceed 140 mg. To improve absorption and lessen possible gastrointestinal side effects, it is taken orally, ideally on an empty stomach, at least one hour before or two hours after a meal.

Indications

Cabozantinib 80 mg is prescribed for:

Medullary Thyroid Cancer (MTC): Used in patients with progressive or metastatic MTC who need systemic therapy; Hepatocellular Carcinoma (HCC): Approved for patients who have received sorafenib treatment in the past; Advanced Renal Cell Carcinoma (RCC): As a first-line or second-line therapy for patients with advanced or metastatic kidney cancer.

Mechanism of Action

Cabozantinib functions by inhibiting receptor tyrosine kinases that are implicated in angiogenesis and tumor growth. By preventing the growth of new blood vessels within tumors, VEGFR inhibition stops the malignancies’ supply of oxygen and nutrients. Additionally, cabozantinib inhibits the growth, invasion, and resistance of cancer cells to other treatments by targeting MET and AXL.

Side Effects and Safety Profile

While cabozantinib is an effective anti-cancer agent, it is associated with several side effects, which may vary in severity. Common adverse effects include:

• Fatigue
• Diarrhea
• Nausea and vomiting
• Hypertension (high blood pressure)
• Hand-foot syndrome (palmar-plantar erythrodysesthesia)
• Weight loss
• Decreased appetite

Hepatotoxicity, gastrointestinal perforation, thromboembolism, and osteonecrosis of the jaw are serious but uncommon adverse effects. To properly manage these risks, patients receiving cabozantinib medication need to have their blood pressure, liver function, and overall disease progression regularly monitored.

Drug Interactions

Because CYP3A4 is the primary enzyme responsible for cabotinib’s metabolism, it may interact with medications that stimulate or inhibit this enzyme. While ketoconazole, clarithromycin, and grapefruit juice may raise cabozantinib levels, increasing the risk of toxicity, medications like rifampin, phenytoin, and St. John’s wort may lower its effectiveness.

Conclusion

Cabozantinib 80 mg is an essential targeted treatment for a number of malignant tumors. By efficiently slowing tumor growth and development, its multi-kinase inhibitory activity enhances patient survival. To balance effectiveness with possible side effects, its administration necessitates cautious patient selection, dosage modification, and continuous monitoring. Always get medical advice before beginning or altering cabozantinib treatment.

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To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

1. What advantages does cabozantinib offer?
Medullary thyroid cancer that has already spread to other areas of the body is treated with cabotanzantinib capsules. Advanced kidney cancer is treated with cabotanzantinib tablets alone. Additionally, it is utilized as a first-line treatment for advanced kidney carcinoma in conjunction with nivolumab.

2. Which foods are off limits when taking cabozantinib?
It is recommended to take cabotanzantinib empty-handed, either one hour before or two hours after eating. Unless your doctor instructs you otherwise, avoid consuming grapefruit, grapefruit juice, or any supplements containing grapefruit extract while taking cabozantinib.

3. What is the maximum duration of cabozantinib use?
Tyrosine kinase inhibitors like Cabometyx are used until the malignancy worsens or you are unable to continue taking the medication due to negative side effects or reactions.

4. Is cabozantinib associated with hair loss?
Almost always, hair loss is only temporary. After the therapy is over, your hair will typically grow back. Your hair may change color as a result of this treatment.