Indication:
Palcigen capsules, containing 125mg of Palbociclib, are prescribed for treating advanced or metastatic breast cancer that is hormone receptor-positive (HR+) and human epidermal growth factor receptor 2-negative (HER2-).

Pharmacology:
Palbociclib, the active ingredient in Palcigen capsules, acts as a CDK4/6 inhibitor, targeting enzymes that regulate cell cycle progression. By inhibiting these enzymes, Palbociclib disrupts the cell cycle at a specific phase, hindering the proliferation of cancer cells.

Dosage and Administration:
Patients typically take Palcigen capsules orally once daily for 21 days, followed by a 7-day break, constituting a 28-day treatment cycle. The dosage may vary depending on individual patient factors and response to treatment, and it can be taken with or without food.

Interaction:
Palbociclib may interact with various medications, including strong CYP3A inhibitors and inducers, potentially affecting its metabolism and efficacy. Patients should inform their healthcare provider about all medications, supplements, and herbal products they are using to avoid possible interactions.

Side Effects:
Common side effects of Palcigen capsules may include neutropenia, leukopenia, fatigue, nausea, and hair loss. More severe adverse effects like thrombocytopenia, liver problems, and blood clots can also occur. Patients should promptly notify their healthcare provider of any severe or persistent side effects.

Precautions and Warnings:
Patients taking Palcigen capsules should undergo regular monitoring of blood cell counts and liver function tests. Palbociclib may cause harm to a developing fetus, so effective contraception is necessary during treatment and for a period after stopping. Breastfeeding is not recommended while using Palcigen.

Overdose Effects:
In case of Palcigen overdose, patients may experience worsening of side effects such as decreased blood cell counts and gastrointestinal symptoms. Overdose management typically involves supportive care and close monitoring. Immediate medical attention is crucial if overdose is suspected.