Acalabrutinib 100 mg is a small morculin cloth from Brutons Tyrosinkinase (BTK), an enzyme involved in the signal path of B cells. It is primarily used to treat certain types of blood cancers, particularly B-cell malignant tumors. Acarabrutinib is sold under the brand name Calquence and is available as a 100 mg oral capsule. Drugs block BTK and reduce the survival and proliferation of malignant B cells. Compared to older BTK inhibitors, it provides improved selectivity and reduced offact effect.

Uses

Acalabrutinib is prescribed for the treatment of:

Chronic Lymphocytic Leukemia (CLL) – A slow-growing blood cancer that affects lymphocytes.
Small Lymphocyte Lymphoma (SLL) – A CLL-like cancer where cancer cells develop primarily in lymph nodes.

Coat Cell Lymphoma (MCL) – Rare and aggressive non-Hodgkin’s lymphoma, usually treated after other treatments have failed.

It is often used alone or in combination with other cancer treatments, such as obinutuzumab.

Dosage and Administration

Standard Dosage: A typical dose of acarabutinib is 100 mg twice a day (every 12 hours).
Food or not: Capsules should be swallowed with a glass of water. Open, break, bite, crush, crush.

Missed Dose: If the dose is overlooked in less than 3 hours, you should immediately remind yourself. If more than 3 hours have passed, skip the missed dose and continue with the next planned dose. Duration of treatment: Treatment continues until disease progression or unacceptable toxicity develops, as determined by the health care provider.

Side Effects

Like all medications, Acalabrutinib may cause side effects. Some common and serious side effects include:

Common Side Effects:
Fatigue
Headache
Diarrhea
Nausea
Muscle and joint pain
Cough
Easy bruising

Serious Side Effects:

Bleeding problems: Increased risk of serious bleeding (e.g. stomach bleeding, cerebral hemorrhage).

Infection: Acarabutinib reduces the number of white blood cells and can lead to bacterial, viral and fungal infections.

Heart Problems: Rare cases of atrial fibrillation (irregular heartbeat) can occur.

Secondary Cancer: Some patients may develop secondary malignant tumors, such as skin cancer.

Liver Problems: Liver enzymes are observed in some patients. Patients should immediately report serious side effects to their doctor.

Storage Instructions

Store at room temperature (20°C to 25°C/68°F to 77°F).

Hold the medicine in the original container to protect it from moisture.

Avoid heat, light and humidity.

Do not use expired medications.

Precautions and Warnings

Pregnancy and Breastfeeding: Acarabutinib can cause fetal damage. Women should avoid pregnancy during treatment and at least one week after the last dose.

Interaction with drugs: Avoid using potent CYP3A4 inhibitors or inductors (such as rifampin, ketoconazole) as they may affect Acalabrutinib Mirror.

Surgery or dental procedures: Stop acalabrutinib at least 3-7 days before surgery to reduce the risk of bleeding.

Vaccination: Live vaccines during treatment should be avoide.

Conclusion

Acalabrutinib 100 mg is a potent and selective BTK inhibitor for the treatment of CLL, SLL and MCL. It is effective, but requires careful monitoring of side effects, especially bleeding, infections and heart problems. Patients should follow the instructions and storage guidelines for prescribed medications to maintain effectiveness. Always contact your health service provider before starting or stopping treatment.

Order Now At Mdx Pharma bd….

To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

Q. What is acalabrutinib 100mg used for?

Acalabrutinib is used to treat people with mantle cell lymphoma (MCL; a fast-growing cancer that begins in the cells of the immune system) who have already been treated with at least one other chemotherapy medication.

Q. What foods should I avoid with acalabrutinib?

The blood levels of this medication can be affected by certain foods and medications, so they should be avoided. These include: grapefruit, grapefruit juice, Seville oranges (often used in marmalade), St. John’s Wort, itraconazole, erythromycin, fluconazole, rifampin, and diltiazem, among others.

Q. What is the success rate of acalabrutinib?

The overall response rate to acalabrutinib was 73% and three patients (5%) achieved complete remission. At a median follow-up of 35 months, the median progression-free and overall survival were not reached; 24-month estimates were 72% and 81%, respectively.