Pazopanib is a targeted cancer medication that is mainly used to treat specific kinds of advanced tumors. Votrient is the trade name under which it is marketed. The 200 mg strength is typically recommended either by itself or in combination with other strengths to customize the daily dosage based on the patient’s need. It is available as oral tablets. Votrient is a medication that belongs to the tyrosine kinase inhibitor (TKI) class and is approved for the treatment of advanced renal cell carcinoma (RCC) and soft tissue sarcoma (STS) in specific circumstances.

Uses of Pazopanib (Votrient)

Votrient is primarily used to treat:

Advanced Renal Cell Carcinoma (RCC): This is the most common form of kidney cancer in adults. Patients with cancer that cannot be surgically removed or that has spread to other bodily parts should take pazopanib.

Advanced Soft Tissue Sarcoma (STS): This includes a diverse group of cancers arising from the soft tissues such as muscle, fat, blood vessels, and connective tissue. Patients with non-adipocytic STS or those who have already received chemotherapy for metastatic illness are usually treated with pazopanib.

Mechanism of Action

Pazopanib works by inhibiting multiple tyrosine kinases, enzymes that play a key role in the growth, development, and spread of cancer cells. Specifically, it blocks the activity of vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), platelet-derived growth factor receptors (PDGFR-α and PDGFR-β), and c-Kit.

By targeting these receptors, Pazopanib disrupts the blood supply (angiogenesis) that tumors need to grow and thrive. This slows the progression of the disease and, in many cases, helps shrink the tumor size.

Dosage and Administration

800 mg once day is the recommended starting dose of Pazopanib, which is often given empty-handed (either an hour before or two hours after a meal). To get this entire dosage, the 200 mg pill is frequently combined with other strengths. Nonetheless, the dosage could be changed in light of:

Drug tolerance

The existence of adverse effects

function of the liver

Drug interactions

The tablet must be swallowed whole; do not chew, break, or crush it. The best benefits come from constant daily dosing.

Side Effects

Pazopanib 200 mg (Votrient) has a number of possible adverse effects, despite its potential for cancer control. Typical ones consist of:

Having diarrhea

Hypertension, or elevated blood pressure,

Vomiting and feeling queasy

Appetite loss

Changes in hair color (typically lighter)

Weariness

Loss of weight

Liver poisoning (higher liver enzymes; it’s crucial to have regular liver function tests)

Heart problems like heart failure or QT prolongation

Thrombotic incidents, such as strokes or blood clots

Bleeding or intestinal perforation

A uncommon neurological disorder known as reversible posterior leukoencephalopathy syndrome (RPLS)

Symptoms including chest pain, a strong headache, yellowing of the skin or eyes, disorientation, or swelling in the legs or feet should be reported very away by patients.

Precautions and Warnings

Patients should let their doctor know before beginning Pazopanib if they have:

Liver illness

Heart issues or a past heart attack

Bleeding disorder history

Recent or upcoming surgery

elevated blood pressure

Drug Interactions: The liver enzyme CYP3A4 metabolizes pazopanib. As a result, it might interfere with drugs that strongly inhibit or stimulate this enzyme. Among the examples are:

Clarithromycin, ketoconazole, and grapefruit juice are inhibitors that may increase Pazopanib levels.

Antacids and proton pump inhibitors should not be taken by patients shortly before taking Votrient since they may interfere with absorption.

Pregnancy and Breastfeeding: Pazopanib should not be used during pregnancy since it may harm the fetus. During and for a while following therapy, effective contraception must be utilized. During treatment, breastfeeding is also discouraged.

Storage and Handling

Store Pazopanib tablets at room temperature, away from excess heat and moisture. Keep the medication out of children’s and pets’ reach and in its original container. Do not use expired medication, and dispose of unused tablets safely following local pharmaceutical disposal guidelines.

Conclusion

An important development in the treatment of advanced tumors such as soft tissue sarcoma and RCC is the 200 mg dosage of pozopanib (Votrient). Although there is no cure, it can help many patients manage the course of their condition and enhance their quality of life. It requires careful monitoring by a healthcare professional due to possible interactions and negative effects. For this potent cancer-fighting drug to be used safely and effectively, patients must closely follow their doctor’s dosage instructions and report any unexpected symptoms right once.

Order Now At Mdx Pharma bd….

To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

1. What is the purpose of azopanib (Votrient)?
Pazopanib is mainly used to treat advanced soft tissue sarcoma and advanced renal cell carcinoma (kidney cancer) in individuals who have already had chemotherapy.

2. Pazopanib: How does it work?
The tyrosine kinase inhibitor (TKI) pazopanib slows or stops the growth of malignancies by blocking the enzymes that cause cancer cells and the blood vessels that supply them to proliferate.

3. What is the typical Pazopanib dosage?
800 mg taken once daily on an empty stomach is the recommended starting dose. The 200 mg pills give you the freedom to change the dosage in response to adverse effects or tolerance.

4. How should I take Pazopanib 200 mg?
Take it at least one hour before or two hours after a meal, and swallow the tablets whole without crushing or chewing. Take it every day at the same time.

5. Is it possible for Pazopanib to interact with other drugs?
Pazopanib may communicate with:
Some antifungals and antibiotics (like ketoconazole)
Inhibitors of proton pumps, such as omeprazole
Blood thinners (warfarin, for example)
Other medications for cancer
Every prescription and supplement you take should be disclosed to your doctor.