Lynparza (active ingredient: Olaparib) is a targeted cancer therapy used mainly for treating specific types of cancers, such as ovarian, breast, pancreatic, and prostate cancers. Olaparib is a revolutionary treatment designed for cancers caused by defects in DNA repair mechanisms, particularly those involving mutations in the BRCA1 or BRCA2 genes. It belongs to a class of drugs called PARP inhibitors (Poly ADP-Ribose Polymerase inhibitors).

Mechanism of Action

Olaparib works by exploiting the concept of synthetic lethality, targeting the PARP enzyme that plays a crucial role in repairing damaged DNA. In patients with BRCA-mutated cancer cells, the ability to repair DNA damage is already compromised. By inhibiting PARP enzymes, Olaparib prevents the cancer cells from repairing their DNA, leading to accumulation of genetic damage and ultimately, cell death. This selectivity allows Olaparib to preferentially target cancer cells while minimizing damage to healthy tissue.

Indications and Uses

Olaparib 150 mg is indicated for the treatment of:

Advanced ovarian cancer with BRCA mutations, particularly in patients who have responded to platinum-based chemotherapy.

HER2-negative, BRCA-mutated metastatic breast cancer.

Metastatic pancreatic cancer in patients with a germline BRCA mutation.

Metastatic castration-resistant prostate cancer (mCRPC) with homologous recombination repair (HRR) gene mutations, including BRCA1 and BRCA2.

The drug is often used either as maintenance therapy to delay cancer progression after chemotherapy or as a standalone treatment in patients with specific genetic profiles.

Dosage and Administration

Each Olaparib (Lynparza) tablet contains 150 mg of the active substance. The usual adult dosage is:

300 mg taken orally twice daily, which equates to two 150 mg tablets per dose.

It is important to swallow the tablets whole and not to chew, crush, or split them. Olaparib should be taken at the same time each day, with or without food, to maintain consistent blood levels. Dosing may be adjusted based on the patient’s tolerance, kidney function, or if adverse effects occur.

Pharmaceutical Form

The active component of Olaparib (Lynparza) 150 mg is present in each tablet at a dosage of 150 mg. The standard adult dosage is:

300 mg orally each day split into two doses, which means two 150 mg tablets for each dose.

Swallowing the tablets whole is crucial; do not chew, crush, or break them. To ensure steady blood levels, Olaparib should be administered daily at the same time, regardless of meals. The dose may be modified depending on the patient’s tolerance, kidney function, or if adverse effects arise.

Side Effects and Risks

Olaparib, like all medications, can lead to side effects. Typical negative effects comprise:

Exhaustion or frailty

Vomiting and nausea

Low red blood cell counts (anemia)

Lowered white blood cell or platelet levels

Appetite loss

Durchfall

Cephalalgia

Pneumonitis (lung inflammation) and secondary cancers like leukemia or myelodysplastic syndrome are more serious but less common side effects. While receiving treatment, patients should have frequent blood tests and monitoring to identify any complications at an early stage.

Precautions

Prior to commencing treatment with Olaparib, patients need to notify their healthcare provider about:

Any past issues with blood disorders or lung problems.

Expecting a baby or intending to get pregnant. Olaparib can be damaging to a fetus.

Plans for breastfeeding, given that it is not advised during treatment and for some time following the final dose.

Other medications currently used, because of possible drug interactions.

Storage and Handling

Olaparib tablets need to be kept at room temperature, protected from moisture and heat. Store the medication out of children’s reach and do not use it after its expiration date.

Conclusion

Olaparib (Lynparza) 150 mg marks a notable progress in the field of personalized cancer treatment. It provides a more effective and less toxic alternative to conventional chemotherapy by focusing on tumors with specific genetic mutations. Olaparib remains essential in the changing field of cancer therapies, thanks to its oral administration, proven clinical effectiveness, and tolerable side effects. Treatment with Olaparib, like any cancer therapy, should be closely monitored by a healthcare professional, and patients are advised to talk to their medical team about any concerns or side effects.

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To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

1. What is the purpose of Olaparib (Lynparza)?
Olaparib, a PARP inhibitor, is utilized in the treatment of specific cancer types, such as ovarian, breast, pancreatic, and prostate cancers. Patients with mutations in the BRCA1 or BRCA2 genes frequently use it.

2. What is the mechanism of action for Olaparib?
Olaparib inhibits PARP enzymes that assist in repairing cellular DNA damage. This obstruction results in the death of cancer cells with BRCA mutations, thereby aiding in the deceleration or cessation of tumor growth.

3. How should Olaparib 150 mg be taken?
It is usually taken orally twice daily, approximately 12 hours apart, with or without food. The dose may vary based on your condition and response to treatment.

4. Can Olaparib cause side effects?
Yes. Common side effects include nausea, fatigue, anemia, vomiting, decreased appetite, and diarrhea. Serious side effects may include bone marrow suppression or blood disorders.

5. In case I forget to take a dose, what should my course of action be?
Should the interval since the missed dose be less than 2 hours, take it immediately. If the time that has passed is greater than 2 hours, skip the dose that was missed and go on with the usual schedule. Do not double up.

6. Is it safe to use Olaparib while pregnant or breastfeeding?
Olaparib can be detrimental to an unborn child. During treatment and for 6 months after the last dose, effective contraception is necessary. While taking this medication and for one month after discontinuation, do not breastfeed.