Hydroxyurea USP 500 mg (Droxia) is a medication primarily used to treat sickle cell disease, certain types of cancer (like chronic myelogenous leukemia (CML)), and polycythemia vera. It works by slowing down the production of certain cells in the body, helping to reduce the risk of painful episodes in sickle cell disease and manage the growth of cancer cells.

Hydroxyurea USP 500 mg (Droxia)

Product Overview: Hydroxyurea USP 500 mg (Droxia) is an oral medication used to treat sickle cell disease, chronic myelogenous leukemia (CML), and polycythemia vera. Droxia works by inhibiting the production of DNA synthesis in certain cells, slowing down the rate of cell division. In sickle cell disease, it helps increase the production of fetal hemoglobin, reducing the occurrence of painful sickle cell crises and improving overall health.

Key Benefits:

• Effective in treating sickle cell disease by reducing painful episodes (crises) and improving hemoglobin levels.
• Used as part of the treatment regimen for chronic myelogenous leukemia (CML) and polycythemia vera.
• Reduces the need for frequent blood transfusions in sickle cell patients.
• Oral administration makes it easier for patients to adhere to treatment schedules.

Indications:

• Sickle Cell Disease: Hydroxyurea is used to reduce the frequency of painful episodes and reduce the need for blood transfusions.
• Chronic Myelogenous Leukemia (CML): Used in certain stages of CML as part of a combination therapy to control abnormal white blood cell production.
• Polycythemia Vera: Hydroxyurea is used to treat this blood disorder, where too many red blood cells are produced.

Dosage:

• The typical dose for Hydroxyurea USP 500 mg (Droxia) varies based on the condition being treated.
  • Sickle Cell Disease: The starting dose is usually 15 mg/kg/day and may be adjusted depending on individual response.
  • Chronic Myelogenous Leukemia (CML): The usual starting dose is 400-600 mg daily, which can be adjusted depending on tolerance.
  • Polycythemia Vera: The recommended dose is generally 500 mg daily but may vary depending on individual response.
• Hydroxyurea should be taken once daily and may be taken with or without food.

Precautions:

• Bone marrow suppression: Hydroxyurea can affect blood cell production, leading to low white blood cell counts, anemia, and thrombocytopenia. Regular blood tests are needed to monitor blood counts.
• Pregnancy and breastfeeding: Hydroxyurea can cause birth defects, so it should not be used during pregnancy or while breastfeeding unless absolutely necessary.
• Liver and kidney function: Hydroxyurea can affect liver and kidney function. Your healthcare provider will monitor liver and kidney function regularly.
• Use in combination: Hydroxyurea is often used in combination with other therapies, so it is essential to follow your healthcare provider’s guidance closely.

Common Side Effects:

• Bone marrow suppression (low blood cell counts)
• Nausea and vomiting
• Fatigue
• Hair loss (temporary)
• Mouth sores
• Skin rash
• Anemia (low red blood cells)
• Increased risk of infection due to low white blood cell count

Packaging:

• Hydroxyurea USP 500 mg (Droxia) tablets are available in secure packaging to ensure safe handling and administration. Each bottle contains [insert quantity] tablets.

Important Notes:

• Regular monitoring: You will need regular blood tests to monitor your white blood cell count, red blood cell count, and platelet count while using Hydroxyurea.
• Adherence to dosage: Always take Hydroxyurea exactly as prescribed. Do not stop or adjust the dose without consulting your healthcare provider.
• Storage: Store Hydroxyurea in a cool, dry place, away from moisture and direct sunlight, and out of reach of children.