Hertinib 40 mg is a prescription drug that contains Neratinib as its active ingredient. Neratinib is a tyrosine kinase inhibitor (TKI) mainly used to treat early-stage HER2-positive breast cancer. Produced according to strict pharmaceutical regulations, Neratinib provides an effective oral treatment choice for patients who have previously received trastuzumab-based therapy. It aids in lowering the risk of cancer recurrence by targeting HER2 receptors, offering an essential protective measure in the management of breast cancer.

Composition and Packaging

Neratinib tablets contain:

Aktiv Inhaltsstoff: Neratinib 40 mg

Darreichungsform: Filmtabletten

Packaging: Typically offered in blister packs containing either 30 or 180 tablets, based on the prescribed treatment regimen.

Mechanism of Action

Neratinib functions by permanently attaching to and hindering the activity of HER1, HER2, and HER4 receptors, which belong to the epidermal growth factor receptor (EGFR) family. Certain aggressive forms of breast cancer exhibit HER2 overexpression. Neratinib helps to prevent breast cancer from returning after initial treatment by blocking these receptors, which disrupts the growth and spread of cancer cells.

Indications

The use of Neratinib 40 mg is authorized in:

Prolonged adjuvant treatment of adult patients with early-stage HER2-positive breast cancer

It is particularly advised for patients who have undergone adjuvant therapy based on trastuzumab in the last two years.

With medical oversight, it may also be studied or used off-label for other HER2-positive cancers.

Dosage and Administration

The advised Neratinib (which consists of six tablets of 40 mg each), to be taken orally once a day with a meal.

A healthcare professional usually recommends a treatment duration of 12 months.

Loperamide is often prescribed to patients as a preventive measure during the first two months of therapy to manage potential diarrhea, which is a common side effect of Neratinib.

Important: Always adhere to the prescribed medication regimen exactly. Before making any changes to the dosage, consult your physician.

Side Effects

As with all drugs, Neratinib can lead to side effects. Typical side effects are:

Diarrhea (the most commonly reported)

Vomiting and nausea

Müdigkeit

Abdominal discomfort

Appetite loss

Dermatitis

Increase in liver enzymes

With early supportive care, most side effects can be managed effectively. In the case of severe diarrhea, it may be necessary to adjust the dosage or temporarily stop treatment.

Patients should be monitored regularly for liver function and hydration status, particularly during the first few weeks of treatment.

Precautions and Warnings

Pregnancy and Breastfeeding: Neratinib can be harmful to the fetus and is not advised for use during pregnancy or breastfeeding.

Liver Impairment: Caution is advised for patients with liver dysfunction when using Neratinib.

Drug Interactions: Neratinib might interact with proton pump inhibitors, antacids, and other substances that inhibit or induce CYP3A4. Tell your doctor about all the medications you are using.

Storage Instructions

Keep in a dry location, away from direct sunlight, and at a temperature below 25°C (77°F).

Ensure that children cannot reach it.

Do not use after the date of expiration indicated on the package.

Why Choose (Neratinib)?

With clinical backing, it reduces the risk of breast cancer recurrence.

Provides an oral treatment option that is non-invasive

Produced with strict quality controls in place

Frequently applied alongside supportive treatments to enhance tolerability.

Availability

Hertinib is available through specialty pharmacies and authorized distributors. Depending on regional regulations, it may be available under compassionate use or patient assistance programs in certain countries. Always obtain Hertinib through a licensed healthcare provider or pharmacy to ensure authenticity.

Order Now At Mdx Pharma bd….

To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

1. What is the purpose of Neratinib 40 mg?
Neratinib is utilized for treating early-stage HER2-positive breast cancer in patients who have finished trastuzumab (Herceptin) treatment. In some cases, it may also be applicable for advanced or metastatic HER2-positive breast cancer.

2. What is the mechanism of action of Neratinib?
Neratinib is a tyrosine kinase inhibitor that obstructs the HER2 receptor, thereby hindering the proliferation and dissemination of cancer cells that exhibit an overexpression of the HER2 protein.

3. What is the method of administration for Hertinib?
It is consumed by mouth, typically once daily, along with food. The usual daily dosage is 240 mg, corresponding to six tablets of 40 mg each. Always adhere to your physician’s guidance.

4. Is it safe to take Neratinib alongside other medications?
Neratinib may interact with certain medications, including:
Protonenpumpeninhibitoren (z. B. Omeprazol)
Magenmittel
Some antifungals
CYP3A4 enhancer or suppressor
Always inform your doctor about any medications or supplements you are using.

5. What is the typical duration of treatment with Neratinib?
In cases of early-stage breast cancer, it is usually prescribed for one year (around 12 months), contingent on the patient’s response and tolerance.

6. Can side effects such as diarrhea be diminished?
It is common for doctors to suggest beginning preventive treatment with loperamide on the first day of therapy and maintaining it for at least the first two months.