Ertugliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor included in the prescription oral drug Ertugliflozin 15 mg. By assisting in blood glucose control, it is mostly used to treat type 2 diabetes mellitus in adults. Ertugliflozin 15 mg is a contemporary type of antidiabetic medications that are manufactured as tablets and function by encouraging the elimination of excess glucose through the urine.

Mechanism of Action

The active component of Ertugliflozin, ertugliflozin, affects the kidneys. It specifically inhibits the proximal renal tubules’ SGLT2 protein. Under typical conditions, SGLT2 returns glucose from the urine to the circulation. Ertugliflozin lowers blood sugar levels by inhibiting this transporter, which also improves glucose excretion through urine and decreases glucose reabsorption. Because this pathway is insulin-independent, people with decreased insulin sensitivity or secretion can still benefit from it.

Indications and Usage

The following conditions are treated with Ertugliflozin:

Type 2 Diabetes Mellitus (T2DM): To enhance glycemic control in adults, in addition to diet and exercise.

It can be taken either alone or in conjunction with other antidiabetic drugs, including insulin, DPP-4 inhibitors, sulfonylureas, or metformin.

In certain situations, people with established heart disease may be administered it to lower their risk of cardiovascular events.

Note: Diabetic ketoacidosis and type 1 diabetes mellitus are not conditions for which Ertugliflozin is recommended.

Dosage and Administration

Beginning Dosage: 5 mg of Ertugliflozin should normally be taken once daily in the morning, with or without breakfast.

Maximum Dosage: The dose may be raised to 15 mg once daily if it is tolerated and more glycemic control is required.

To prevent hypoglycemia, it is crucial to strictly adhere to the doctor’s dosage instructions, particularly when taking it with other glucose-lowering medications.

Benefits of Ertugliflozin 15 mg

Good Glycemic Control: Assists in reducing fasting blood glucose and HbA1c levels.

Weight Reduction: Encourages modest weight loss by excreting glucose, which reduces calories.

Blood Pressure Reduction: Could help lower systolic blood pressure somewhat.

Cardiovascular Benefits: Patients with heart disease have been proven to have a lower cardiovascular risk in clinical trials.

Low Risk of Hypoglycemia: When used alone, there is little chance of hypoglycemia because it functions without insulin.

Precautions and Warnings

Patients should disclose any of the following conditions to their healthcare professional before taking Ertugliflozin 15 mg:

Kidney issues: Patients with significant renal impairment (eGFR <30 mL/min/1.73 m2) should not take ertugliflozin.

Use caution when administering to people who have liver illness.

Regular vaginal yeast infections or urinary tract infections: The drug may make these illnesses more likely.

Low blood pressure or dehydration: The medication’s diuretic properties may result in or exacerbate dehydration.

Limited information is available regarding use during pregnancy and lactation. Only when necessary and under close medical supervision should it be used.

Potential Side Effects

Ertugliflozin is generally well tolerated by patients, while some may have adverse effects. Typical and dangerous adverse effects include:

Typical adverse effects:

An increase in urination

Yeast infections in the genitalia (particularly in women)

Infections of the urinary tract

Dry tongue and thirst

Lightheadedness or dizziness

Serious Adverse Reactions:

Even when blood sugar levels are normal, ketoacidosis can occur (euglycemic DKA).

Severe infections of the urinary tract

Acute damage to the kidneys

Perineal necrotizing fasciitis (rare yet dangerous)

Low blood pressure, particularly in diuretic-using or elderly people

You should notify a healthcare professional right away if you experience any severe or ongoing symptoms.

Drug Interactions

Ertugliflozin could have interactions with:

Diuretics: A higher chance of low blood pressure and dehydration

The risk of hypoglycemia may be increased by insulin or insulin secretagogues.

Dosage adjustments may be required for additional antidiabetic medications.

To prevent drug interactions, always provide your doctor with a complete list of all the medications you are currently taking.

Storage and Handling

Ertugliflozin 15 mg tablets should be kept between 15°C and 30°C at room temperature.

Keep out of children’s reach and away from moisture and bright sunlight.

Conclusion

For people with type 2 diabetes who require more glycemic control than lifestyle modifications and first-line treatments, Ertugliflozin 15 mg (ertugliflozin) is a potent and successful medicine. It is a useful tool in the current diabetes therapy toolbox, offering advantages including weight loss and cardiovascular protection. To guarantee safety and the best possible outcomes, it should be administered under a doctor’s supervision, just like any medications.

Order Now At Mdx Pharma bd….

To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

1. What is the purpose of 15 mg of Ertugliflozin?
Ertugliflozin, which is found in Ertugliflozin 15 mg, is used in conjunction with diet and exercise to help persons with type 2 diabetes lower their blood sugar levels.

2. Ertugliflozin: How does it work?
It is a member of the SGLT2 inhibitor medication class. It functions by assisting the kidneys in eliminating extra glucose through urine.

3. Can individuals with kidney disease safely take 15 mg of Ertugliflozin?
It may not be safe or effective in persons with severe kidney dysfunction. Kidney function must be routinely monitored.

4. What are Ertugliflozin 15 mg’s typical adverse effects?
Urinating a lot
A rise in thirst
Infections with genital yeast
Infections of the urinary tract
Low blood sugar (while taking other medications for diabetes).

5. Is it possible to combine Ertugliflozin with other diabetes drugs?
Indeed, it is frequently taken with insulin or metformin, but dosage changes can be required.