The targeted therapy medication cabotinib is a type of tyrosine kinase inhibitor (TKI). It is mostly used to treat various cancers, such as renal cell carcinoma (RCC), hepatocellular carcinoma (HCC), and medullary thyroid cancer (MTC). The drug works by inhibiting many receptor tyrosine kinases that are involved in tumor growth, angiogenesis (the formation of new blood vessels), and cancer cell spread.

Composition and Dosage

Cabozantinib comes in pills containing 20 mg, 40 mg, and 60 mg of the drug. Along with excipients such lactose monohydrate, magnesium stearate, microcrystalline cellulose, and other inert components that aid in tablet manufacturing, the 20mg formulation includes the active substance Cabozantinib (S)-malate. The particular ailment being treated and the patient’s reaction to treatment determine the cabozantinib dosage.

Usually, a starting dose of 60 mg once daily is recommended for advanced renal cell carcinoma, and the same is true for hepatocellular carcinoma. The medicine may be changed to 40 mg or 20 mg per day if side effects require a dose reduction.

Mechanism of Action

Several tyrosine kinases, such as MET (mesenchymal-epithelial transition factor), AXL, RET (rearranged during transfection), and VEGFR (vascular endothelial growth factor receptor), are inhibited by cabotinib. Through the inhibition of these receptors, cabozantinib aids in:

The development of tumor blood vessels is necessary for tumor growth, and this can be achieved by reducing angiogenesis.

Slowing or halting the development and spread of cancer cells via inhibiting tumor cell proliferation.

By preventing metastasis, the cancer’s capacity to spread to other bodily areas is reduced.

Indications and Uses

Cabozantinib 20mg is prescribed in various cancer treatments, including:

One form of kidney cancer for which cabozantinib is utilized as a first- or second-line treatment is renal cell carcinoma (RCC).

Hepatocellular Carcinoma (HCC): Liver cancer in which sorafenib has been utilized in the past.

Useful when the cancer is metastatic or incurable is Medullary Thyroid Cancer (MTC).

Administration and Precautions

It is recommended to take cabotizantinib empty-handed, that is, at least one hour before or two hours after meals.

Tablets should be swallowed whole with water; do not chew or crush them.

Steer clear of grapefruit and grapefruit juice since they may change how the medication is metabolized.

Side Effects

Like any cancer medication, cabozantinib can cause side effects, including:

• Fatigue, nausea, diarrhea
• High blood pressure (hypertension)
• Hand-foot syndrome (redness, swelling, pain in hands and feet)
• Loss of appetite, weight loss
• Increased liver enzymes

If a patient has serious adverse effects, such as bleeding, severe diarrhea, or indications of liver toxicity, they should see their doctor right away.

Conclusion

For patients with RCC, HCC, and MTC, Cabozantinib 20mg is a potent targeted treatment that has greatly enhanced results. It should be used under close medical care, nevertheless, because of possible interactions and adverse consequences.

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1. What is the purpose of 20 mg of Caboxen?
Renal Cell Carcinoma: Patients with advanced renal cell carcinoma (RCC) may be treated with caboxen. Hepatocellular Carcinoma: Patients with hepatocellular carcinoma (HCC) who have received prior Sorafenib treatment may benefit from Caboxen.

2. What is the maximum duration of cabozantinib use?
Tyrosine kinase inhibitors like Cabometyx are used until the malignancy worsens or you are unable to continue taking the medication due to negative side effects or reactions.

3. When is the best time to take cabozantinib?
With nivolumab + cabozantinib, the median time to response was 2.8 months (range: 1.0 to 19.4), while with sunitinib, it was 4.2 months (range: 1.7 to 12.3).

4. Does hair loss occur when using cabozantinib?
Alopecia is a common (≥1/100 to <1/10) or very common (≥1/10) adverse event that occurs with multikinase inhibitors, such as cabozantinib, lenvatinib, regorafenib, dasatinib, pazopanib, and sorafenib.

5. What safety measures are in place for cabozantinib?
You have the risk of getting gastrointestinal perforations and fistulas, which are irregular openings in your digestive tract, if you take cabotizantinib. If you have a fever, severe diarrhea, or severe abdominal pain, let your doctor know. Cabozantinib may make blood clots more likely to occur.

6. What is cabozantinib 20 mg’s brand name?
There are several brand names for cabotinib, including Cometriq and Cabometyx.

7. At what point does cabozantinib begin to function?
What is the duration required for Cabometyx to begin functioning? After your initial dosage, Cabometyx begins to operate. You probably won’t feel the effects of the medicine on your body because of the way it functions. However, throughout therapy, your doctor will keep an eye on you to see if the medication is helping to address your illness.