Briganix (brigatinib) 180 mg
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BRIGANIX 180 mg is designed for the treatment of individuals with metastatic non-small cell lung cancer (NSCLC) that is positive for anaplastic lymphoma kinase (ALK) and who have either not responded to or cannot tolerate crizotinib. The approval for use in this context is granted on a provisional basis, relying on data regarding the rate and duration of tumor response. The ongoing authorization for BRIGANIX in treating this condition is dependent on the future confirmation and detailed reporting of its clinical benefits in further trials.
Overview of Briganix 90mg Tablets
Composition: Contains Brigatinib 90mg.
– Substitutes: Trepmac, Alunbrig.
– Shipping Class: Room Temperature.
Uses
– Primary Use: Treats a specific type of lung cancer known as non-small cell lung cancer (NSCLC) by inhibiting the growth of cancer cells.
Side Effects
–Common Side Effects: May include nausea, vomiting, diarrhea, loss of appetite, abdominal pain, constipation, fatigue, dizziness, fever, headaches, insomnia, or joint pain. If these persist or worsen, contact a healthcare professional.
How to Use
-Administration Instructions: Take orally with or without food as prescribed by a healthcare provider. Swallow tablets whole without crushing or chewing.
Mechanism of Action
–Function: Acts as an anaplastic lymphoma kinase (ALK) inhibitor, demonstrating significant effectiveness in treating ALK-positive NSCLC.
Important Information
– Monitoring for Pulmonary Reactions: Watch for symptoms of interstitial lung disease/pneumonitis, especially within the first week of treatment.
– Blood Pressure Management: Manage blood pressure before starting treatment; monitor after two weeks and monthly thereafter.
– Heart Rate Monitoring: Be aware of potential bradycardia; monitor heart rate and blood pressure regularly.
– Visual Disturbances: Report any changes in vision.
– Muscle Health: Increased creatine phosphokinase (CPK) levels can occur; report unexplained muscle symptoms and monitor CPK levels.
– Pancreatic Enzymes: Monitor lipase and amylase levels due to potential increases.
– Blood Sugar Levels: Assess and monitor fasting serum glucose; adjust antihyperglycemic medications as needed.
Warnings and Precautions
– Alcohol: May exacerbate dizziness or vision issues; limit alcohol consumption.
– Pregnancy: Potential to harm the fetus; evaluate risks and benefits.
– Lactation: Not recommended due to potential risk to the infant; consult a doctor before breastfeeding.
– Driving: Exercise caution due to possible dizziness or vision blur.
– Kidney Function: Use cautiously in patients with kidney disease; monitor kidney function closely.
– Liver Function: Use cautiously in patients with liver disease; monitor liver function closely.
Missed Dose Guidance
– If a dose is missed, skip it and continue with the next dose at the regular schedule. Do not double the dose.
Product Name | Briganix |
---|---|
Generic Name | Brigatinib |
Formulation | Tablet |
Available Pack Size | 30’s Pot |
Available Strength | 90 mg, 180 mg |
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