For postmenopausal women and men with HR-positive, HER2-negative, and PIK3CA-mutant advanced or metastatic breast cancer, fulvestrant is taken in combination with a prescription medication called alpelisib (Piqray) 150 mg. It belongs to the class of PI3K inhibitors, which selectively target the PIK3CA mutation to restrict the proliferation of tumor cells. Novartis manufactures it, and it is taken orally as pills.

Uses

Alpelisib is indicated for patients with:

Breast cancer that is HER2-negative and hormone receptor-positive (HR-positive). Breast cancer that is advanced or metastatic and has a verified PIK3CA mutation. development of the disease following endocrine therapy. Since the medication particularly targets the PIK3CA mutation, it is not advised for patients who do not have this genetic modification.

Dosage & Administration

A initial dose of 300 mg (two 150 mg tablets) taken orally with meals is advised. The dosage may be lowered to 250 mg or 200 mg daily in the event of negative reactions. The next scheduled dose should be taken at the regular time if a dose is missed by more than nine hours. Never take two doses to compensate for one that was missed. Do not chew, split, or crush tablets; instead, consume them whole.

Dosage Adjustments

Dose adjustments may be required in cases of:

severe adverse effects, such as diarrhea, dermatitis, or hyperglycemia
Hepatic or renal dysfunction
Interactions between drugs and potent CYP3A4 inducers or inhibitors

Adverse Reactions
Typical Side Effects
Increased blood sugar levels, or hyperglycemia
Having diarrhea
Vomiting and nausea
Skin reactions and rashes
Weariness
Appetite loss
Stomatitis, or ulcers in the mouth
Serious Adverse Reactions
High blood sugar levels that can cause ketoacidosis
Inflammation of the lungs, or pneumonia
Toxicology of the liver
Low levels of blood cells
Patients should get medical help right away if they are having severe symptoms.

Precautions & Warnings

Patients with diabetes should keep a careful eye on their blood sugar levels. Steer clear of grapefruit juice since it could affect how the medication is metabolized. Before using, patients with a history of severe allergic reactions should speak with a physician. Effective contraception is recommended for women of reproductive potential since alpelisib may harm the fetus. During treatment and for at least a week following the last dosage, breastfeeding is not advised.

Drug Interactions

Alpelisib may interact with:

CYP3A4 inducers, such as carbamazepine and rifampin It might lessen the effectiveness of CYP3A4 inhibitors, including ketoconazole. It could make things more poisonous. medications that alter blood sugar levels, such as metformin and insulin.

Instructions for Storage
Store in a dry location below 30°C (86°F).
To keep tablets safe from moisture, keep them in their original blister packaging.
Keep out of the refrigerator and away from extreme humidity.
Keep out of children’s reach.

Conclusion

Alpelisib 150 mg is an effective targeted treatment for patients with HR-positive, HER2-negative, PIK3CA-mutated breast cancer. Despite all of its benefits, it needs to be closely monitored because to potential side effects, especially skin reactions and hyperglycemia. To guarantee safe and effective use, always heed your doctor’s advice.

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Q. How long is alpelisib safe to take?

As long as the medication is effective and you are not having too many side effects, you typically continue taking fulvestrant with alpelisib.

Q. How many chemotherapy rounds are typical?

Typically, a chemotherapy regimen consists of four to eight treatment cycles. You take a rest following each treatment session. Your body can heal as a result. For instance, you might receive therapy on the first, second, and third days of your four-week cycle.