Empagliflozin is an oral medication that belongs to the class of medications known as sodium-glucose co-transporter 2 (SGLT2) inhibitors. It is commonly sold under the Jardiance name and is used to help persons with type 2 diabetes control their blood sugar levels. Empagliflozin reduces glucose reabsorption in the kidneys by blocking SGLT2, which increases glucose excretion through urine.

The strength indicator is debossed on the yellow, spherical, film-coated 20 mg tablets. These oral drugs contain magnesium stearate, lactose monohydrate, hydroxypropyl cellulose, microcrystalline cellulose, and empagliflozin as an active component.

Uses

Empagliflozin 20 mg is primarily prescribed for:

When paired with diet and exercise, type 2 diabetes mellitus (T2DM) can help lower blood sugar levels. Heart Failure: In individuals with heart failure with decreased ejection fraction (HFrEF), it lowers the risk of cardiovascular death and hospitalization. Chronic Kidney Disease (CKD): Lowers the risk of cardiovascular problems and helps halt the disease’s course. Cardiovascular Protection: Reduces diabetic patients’ risk of heart attacks, strokes, and other heart-related disorders. For people with type 1 diabetes or diabetic ketoacidosis (DKA), empagliflozin is not advised.

Dosage and Administration

Recommended Dosage:

Adults often begin taking 10 mg once daily in the morning. The dosage may be raised to 20 mg once daily, depending on how the patient responds. With or without food, the tablet should be consumed whole.

Missed Dose:

Take the missed dose as soon as you recollect it. If the next dose is soon due, skip the missed one and carry on with your usual routine. Avoid taking two doses simultaneously.

Overdose:

Dehydration, low blood sugar, and frequent urination are possible symptoms. If you overdose, get medical attention immediately.

Side Effects

Common Side Effects:

Elevated urination
Infections with genital yeast (more prevalent in women)
infections of the urinary tract (UTIs)
Feeling faint, lightheaded, or dehydrated
low blood pressure

Serious Side Effects (Seek Medical Help):

Shortness of breath, nausea, vomiting, and stomach discomfort are signs of ketoacidosis. Severe Hypotension: In dehydrated people, this might cause fainting and shock. Leg edema and decreased urine production are symptoms of acute kidney injury.

Fournier’s Gangrene: An uncommon but dangerous genital infection. Allergic reactions include breathing difficulties, edema, and rash. Note: As the body gets used to the drug, some side effects could go better with time.

Storage Instructions

Keep it between 20°C and 25°C (68°F and 77°F) at room temperature. Avoid direct sunshine and excessive wetness. Avoid keeping items near heat sources or in bathrooms. Keep out of children’s reach. Avoid using after the expiration date.

Precautions and Warnings

Kidney Function: Patients on dialysis or those with severe kidney disease are not advised. Liver Disease: If you have significant liver impairment, see a physician. Dehydration Risk: To avoid dehydration, increase your fluid intake. Risk of Hypoglycemia: Particularly when used with sulfonylureas or insulin. Breastfeeding and pregnancy: Not advised unless directed by a physician.

Conclusion

Empagliflozin 20 mg (Jardiance) is an effective SGLT2 inhibitor used to treat heart failure, type 2 diabetes, and chronic kidney disease. Despite its cardiovascular advantages, there are also potential risks, like dehydration and infections. Always take your drugs as directed by your physician, and promptly report any adverse effects. Adherence to safety protocols and proper preservation ensure the best possible therapeutic outcomes.

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To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

Q. Empagliflozin: is it safe?
You might not notice any difference if you’re taking it for chronic renal disease, but it helps slow the progression of your illness. Do side effects persist over time? Long-term use of empagliflozin is safe. There is no proof that using this medication would negatively impact your overall health.

Q. Does taking empagliflozin affect blood pressure?
In both trial cohorts, empagliflozin reduced blood pressure without increasing heart rate. Additionally, it showed beneficial effects on a measure of cardiac workload, arterial stiffness, and vascular resistance.