The tyrosine kinase inhibitor (TKI) afatinib binds irreversibly to the EGFR family of receptors, which includes HER1, HER2, and HER4.Targeted cancer treatment is its primary use. Afatinib 40 mg tablets are the drug’s most readily available form; they are usually round or oval in shape, film-coated, and taken orally.

Uses of Afatinib 40 mg

For patients with metastatic non-small cell lung cancer (NSCLC) whose tumors include particular EGFR mutations, this therapy is used as a first line of treatment. Lung Squamous Cell Carcinoma: Used following platinum-based chemotherapy progression. Off-label use for HER2-Positive Cancers: It might be taken into consideration for HER2-mutated malignancies in certain circumstances. By obstructing the signals that encourage the growth of cancer cells, afatinib helps slow down their development and spread.

Dosage and Administration

The usual starting dose is 40 mg once daily, taken at least one hour before or two hours after a meal. Sometimes the dosage is adjusted to 30 or 50 mg, depending on the side effects and patient tolerance. The drug is taken continuously until the condition gets worse or there is extreme toxicity.

Missed Dose

Unless the next dose is less than 12 hours away, the missing dose should be taken as soon as possible. If so, proceed with the next planned dose and skip the missing one. Overdose symptoms can include vomiting, nausea, rash, and extreme diarrhea. In the event that an overdose is suspected, get medical help right away.

Side Effects of Afatinib 40 mg

Afatinib can cause various side effects, ranging from mild to severe.Typical Side Effects
The most common adverse effect, diarrhea, can be rather serious.
Skin responses that resemble rashes or acne.

Itching and dry skin.
Stomatitis-related mouth sores.
vomiting and nausea.
Weariness.
Appetite loss.
inflammation of the eyes (dry eyes, conjunctivitis).
Serious Side Effects (Ask for Medical Assistance Right Away).
Dehydration due to severe diarrhea.
Lung issues (cough, breathing difficulties, interstitial lung disease).
severe skin reactions, such as ulcers, blisters, or peeling skin.
Abdominal pain, black urine, and skin or eye yellowing are signs of liver poisoning.
Heart issues (breathlessness, irregular heartbeat, chest pain).

Precautions

Because it may harm the unborn child, it is not advised during pregnancy.

Afatinib should not be taken when nursing.

Patients with heart, kidney, or liver issues should use this product with caution.

Storage and Handling

At room temperature (20–25°C; 68–77°F), keep products. Retain in original packaging to shield from light and moisture. Don’t keep in humid areas or the bathroom. Ensure that children and dogs cannot reach it. In accordance with local laws, dispose of unused or expired medications appropriately.

Conclusion

Lung cancer with an EGFR mutation is the main indication for the targeted treatment afatinib 40 mg. Despite its efficacy, dermatitis, liver damage, and diarrhea are some possible adverse effects. For a medication to be both safe and effective, the right dosage, consistent observation, and timely handling of adverse effects are necessary. For individualized medical advice, always speak with your healthcare practitioner.

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To order from MDX Pharma BD, visit their website at https://mdxpharmabd.com, where you can browse products and place orders online. For inquiries or orders via email, contact emedicarepharma@gmail.com. Alternatively, call (+88) 01929123476. Their address is 29, Abdullahpur, Uttara, Dhaka-1230, Bangladesh.

Q. What kind of medication is afatinib?

Imatinib is a tyrosine kinase inhibitor (TKI), a class of cancer growth blocker. Proteins called tyrosine kinases are used by cells to communicate with one another and promote growth. They serve as messengers of chemicals. Tyrosine kinases come in a variety of forms, and inhibiting them prevents the growth of cancer cells.

Q. Afatinib: is it a chemotherapy drug?

official response. Non-small-cell lung cancer (NSCLC) that is brought on by an aberrant epidermal growth factor receptor (EGFR) gene or genes is treated with the chemotherapeutic medication gliotrif (afatinib). Gilotrif is an EGFR tyrosine kinase inhibitor and small molecule medication.